{ "responseHeader":{ "status":0, "QTime":0, "params":{ "q":"featured:true", "rows":"100000", "wt":"json"}}, "response":{"numFound":7,"start":0,"numFoundExact":true,"docs":[ { "id":"66", "axId":"800163", "a4Version":["0"], "blurb":"
Updated August 2023

The cannabinoid (CB) receptors are two of the most widely expressed GPCRs in the body. When coupled to Gi/o proteins their activation can negatively regulate adenylate cyclase and/or positively regulate MAPK signaling. Conversely, when coupled through Gs proteins, CB1 activation promotes adenylate cyclase signaling. CB1 also modulates a host of ion channels through Gi/o coupling including A-type inwardly rectifying potassium channels (IRK) and N-type and P/Q-type calcium channels (Cav2.2, Cav2.1). The two major functions of these receptors are neuromodulatory, inhibiting neurotransmitter release through retrograde signaling, and immunomodulatory, regulating cytokine release and immune cell migration.

Learn more in the review article ​Cannabinoid Signaling: Insights to Future Pharmacotherapeutic Development.

View a complete list of binding affinity journal articles referenced in this poster here.
", "blurbPlaintext":"Updated August 2023 The cannabinoid (CB) receptors are two of the most widely expressed GPCRs in the body. When coupled to Gi/o proteins their activation can negatively regulate adenylate cyclase and/or positively regulate MAPK signaling. Conversely, when coupled through Gs proteins, CB1 activation promotes adenylate cyclase signaling. CB1 also modulates a host of ion channels through Gi/o coupling including A-type inwardly rectifying potassium channels (IRK) and N-type and P/Q-type calcium channels (Cav2.2, Cav2.1). The two major functions of these receptors are neuromodulatory, inhibiting neurotransmitter release through retrograde signaling, and immunomodulatory, regulating cytokine release and immune cell migration. Learn more in the review article Cannabinoid Signaling: Insights to Future Pharmacotherapeutic Development. View a complete list of binding affinity journal articles referenced in this poster here.", "text1":["Updated August 2023 The cannabinoid (CB) receptors are two of the most widely expressed GPCRs in the body. When coupled to Gi/o proteins their activation can negatively regulate adenylate cyclase and/or positively regulate MAPK signaling. Conversely, when coupled through Gs proteins, CB1 activation promotes adenylate cyclase signaling. CB1 also modulates a host of ion channels through Gi/o coupling including A-type inwardly rectifying potassium channels (IRK) and N-type and P/Q-type calcium channels (Cav2.2, Cav2.1). The two major functions of these receptors are neuromodulatory, inhibiting neurotransmitter release through retrograde signaling, and immunomodulatory, regulating cytokine release and immune cell migration. Learn more in the review article Cannabinoid Signaling: Insights to Future Pharmacotherapeutic Development. View a complete list of binding affinity journal articles referenced in this poster here."], "contentType":"Document", "documentRevisionDate":"2021-09-03T04:00:00Z", "featured":true, "featuredImageFilename":"receptor-poster-highlight.png", "fileUrl":"800163", "itemType":"Lab Wall Posters", "linkFileName":"800163.pdf", "linkFileName2":"800163.pdf", "order":"6600.00000000000", "publishDate":"2016-11-29T05:00:00Z", "requestType":"Both", "reviewDate":"2018-02-04T05:00:00Z", "tagline":"

Updated ​​Cannabinoid Receptors Wall Poster

", "title":"

​Cannabinoid Receptors

", "text10":["

​Cannabinoid Receptors

"], "urlName":"Cannabinoid Receptors", "text100":["Cannabinoid Receptors"], "video":"0", "categories":["Forensic Chemistry & Toxicology", "Neuroscience", "Lipid Biochemistry"], "categoriesNormalized":["forensic_chemistry_and_toxicology", "neuroscience", "lipid_biochemistry"], "_version_":1807987999320834048}, { "id":"68", "axId":"800192", "a4Version":["0"], "blurb":"
Updated Februrary 2024

More than 100 structurally and physiologically distinct cannabinoid compounds are unique to plants of the genus Cannabis, known collectively as phytocannabinoids. Here we present the biosynthesis and degradation pathways of phytocannabinoids derived from the olivetol, varinol, and orcinol series and explain the conventions that have been adopted for nomenclature and structure numbering systems.

To cite this poster: St. Germaine, D.M. ​and Williams, J.B. Phytocannabinoid Guide: Biosynthesis, Naming, and Numbering. February 2024.
", "blurbPlaintext":"Updated Februrary 2024 More than 100 structurally and physiologically distinct cannabinoid compounds are unique to plants of the genus Cannabis, known collectively as phytocannabinoids. Here we present the biosynthesis and degradation pathways of phytocannabinoids derived from the olivetol, varinol, and orcinol series and explain the conventions that have been adopted for nomenclature and structure numbering systems. To cite this poster: St. Germaine, D.M. and Williams, J.B. Phytocannabinoid Guide: Biosynthesis, Naming, and Numbering. February 2024.", "text1":["Updated Februrary 2024 More than 100 structurally and physiologically distinct cannabinoid compounds are unique to plants of the genus Cannabis, known collectively as phytocannabinoids. Here we present the biosynthesis and degradation pathways of phytocannabinoids derived from the olivetol, varinol, and orcinol series and explain the conventions that have been adopted for nomenclature and structure numbering systems. To cite this poster: St. Germaine, D.M. and Williams, J.B. Phytocannabinoid Guide: Biosynthesis, Naming, and Numbering. February 2024."], "contentType":"Document", "documentRevisionDate":"2018-06-01T04:00:00Z", "featured":true, "featuredImageFilename":"phyto-poster-highlight.png", "fileUrl":"800192", "itemType":"Lab Wall Posters", "linkFileName":"800192.pdf", "linkFileName2":"800192.pdf", "order":"6800.00000000000", "publishDate":"2017-08-18T04:00:00Z", "requestType":"Both", "reviewDate":"2021-09-01T04:00:00Z", "tagline":"

​Updated Phytocannabinoid Guide: Biosynthesis, Naming, and Numbering

", "title":"

​Phytocannabinoid Guide: Biosynthesis, Naming, and Numbering

", "text10":["

​Phytocannabinoid Guide: Biosynthesis, Naming, and Numbering

"], "urlName":"Phytocannabinoid Guide", "text100":["Phytocannabinoid Guide"], "video":"0", "categories":["Forensic Chemistry & Toxicology", "Neuroscience"], "categoriesNormalized":["forensic_chemistry_and_toxicology", "neuroscience"], "_version_":1807987999326076928}, { "id":"248", "a4Version":["0"], "blurb":"

Updated February 2024

Nitazenes are one of several types of novel analgesics developed in the 20th century as potential alternatives to traditional opiates. Several novel 2-benzylbenzimidazole opioids have begun to emerge on the illicit market as novel psychoactive substances (NPS). These compounds are structurally different from fentanyl and most are not well characterized, but some have been reported to cause physiological effects similar to heroin, fentanyl, and other opioids. This NPS Snapshot summarizes the structures of the various nitazene compounds as well as key historical dates, prototypical structure, and known pharmacology.

Learn more in the 15-minute webinar on Nitazenes - Emerging Benzimidazole Opioids.

", "blurbPlaintext":"Updated February 2024 Nitazenes are one of several types of novel analgesics developed in the 20th century as potential alternatives to traditional opiates. Several novel 2-benzylbenzimidazole opioids have begun to emerge on the illicit market as novel psychoactive substances (NPS). These compounds are structurally different from fentanyl and most are not well characterized, but some have been reported to cause physiological effects similar to heroin, fentanyl, and other opioids. This NPS Snapshot summarizes the structures of the various nitazene compounds as well as key historical dates, prototypical structure, and known pharmacology. Learn more in the 15-minute webinar on Nitazenes - Emerging Benzimidazole Opioids.", "text1":["Updated February 2024 Nitazenes are one of several types of novel analgesics developed in the 20th century as potential alternatives to traditional opiates. Several novel 2-benzylbenzimidazole opioids have begun to emerge on the illicit market as novel psychoactive substances (NPS). These compounds are structurally different from fentanyl and most are not well characterized, but some have been reported to cause physiological effects similar to heroin, fentanyl, and other opioids. This NPS Snapshot summarizes the structures of the various nitazene compounds as well as key historical dates, prototypical structure, and known pharmacology. Learn more in the 15-minute webinar on Nitazenes - Emerging Benzimidazole Opioids."], "contentType":"Document", "featured":true, "featuredImageFilename":"nitazene-snapshot-highlight.png", "fileUrl":"NPS Snapshot Nitazenes", "itemType":"Guides", "linkFileName":"NPS Snapshot Nitazenes.pdf", "linkFileName2":"NPS Snapshot Nitazenes.pdf", "order":"24800.0000000000", "publishDate":"2020-09-03T04:00:00Z", "requestType":"Downloadable", "reviewDate":"2022-04-12T04:00:00Z", "tagline":"

​Updated Nitazene Snapshot

", "title":"

​NPS Snapshot: Nitazenes

", "text10":["

​NPS Snapshot: Nitazenes

"], "urlName":"NPS Snapshot Nitazenes", "text100":["NPS Snapshot Nitazenes"], "video":"0", "categories":["Forensic Chemistry & Toxicology"], "categoriesNormalized":["forensic_chemistry_and_toxicology"], "_version_":1807987999596609536}, { "id":"325", "a4Version":["0"], "blurb":"The success of mRNA-based COVID-19 vaccines could not have been possible without decades of research on lipid-based drug delivery. Lipid nanoparticles (LNPs) have great potential to revolutionize the development of new therapeutics beyond infectious diseases. From the basic concepts of lipid nano drug delivery to LNP design, preparation, and use – the Lipid Nanoparticle Formulation Guide is packed with simple protocols, resources, and tips to jumpstart your LNP research.

Discover the Latest LNP Research Tools & Resources
", "blurbPlaintext":"The success of mRNA-based COVID-19 vaccines could not have been possible without decades of research on lipid-based drug delivery. Lipid nanoparticles (LNPs) have great potential to revolutionize the development of new therapeutics beyond infectious diseases. From the basic concepts of lipid nano drug delivery to LNP design, preparation, and use – the Lipid Nanoparticle Formulation Guide is packed with simple protocols, resources, and tips to jumpstart your LNP research. Discover the Latest LNP Research Tools & Resources", "text1":["The success of mRNA-based COVID-19 vaccines could not have been possible without decades of research on lipid-based drug delivery. Lipid nanoparticles (LNPs) have great potential to revolutionize the development of new therapeutics beyond infectious diseases. From the basic concepts of lipid nano drug delivery to LNP design, preparation, and use – the Lipid Nanoparticle Formulation Guide is packed with simple protocols, resources, and tips to jumpstart your LNP research. Discover the Latest LNP Research Tools & Resources"], "contentType":"Document", "description":"The Lipid Nanoparticle Formulation Guide is packed with simple protocols, resources, and tips to jumpstart your LNP research.", "featured":true, "featuredImageFilename":"lnp-guide-highlight254701.png", "fileUrl":"Lipid Nanoparticle Formulation", "itemType":"Guides", "linkFileName":"Lipid Nanoparticle Formulation.pdf", "linkFileName2":"Lipid Nanoparticle Formulation.pdf", "order":"32500.0000000000", "publishDate":"2022-06-17T04:00:00Z", "requestType":"Downloadable", "reviewDate":"2023-06-17T04:00:00Z", "tagline":"

​​Lipid Nanoparticle Formulation Guide

", "title":"

​Lipid Nanoparticle Formulation: Basic Concepts & Preparation Procedures

", "text10":["

​Lipid Nanoparticle Formulation: Basic Concepts & Preparation Procedures

"], "urlName":"lipid nanoparticle guide", "text100":["lipid nanoparticle guide"], "video":"0", "categories":["Lipid Biochemistry", "Immunology & Inflammation", "Infectious Disease", "Cancer", "Cell Biology", "Lipid-Based Drug Delivery"], "categoriesNormalized":["lipid_biochemistry", "immunology_and_inflammation", "infectious_disease", "cancer", "cell_biology", "lipid-based_drug_delivery"], "_version_":1807987999747604480}, { "id":"360", "axId":"800246", "a4Version":["0"], "blurb":"

LSD is the classic member of psychedelic lysergamides. Structural modifications to three main regions of the LSD scaffold have resulted in the emergence of new lysergamides entering the novel psychoactive substances (NPS) market.

To support toxicologists and forensic chemists tasked with the identification of these drugs, this poster describes the common naming conventions used for lysergamides and presents common lysergamide substitutions, fragments, and tips for mass spectrometry interpretation to help the forensic community decipher the structure of new lysergamides.

In this guide for lysergamide identification and naming, we review:

Review the list of primary resources used to collate this guide here.

To cite this poster: Watson-Gooden, C., Pierzynski, H., Iula, D.M., and Hering, K.W. Laboratory Guide for Lysergamide Identification and Naming. September 2023.

", "blurbPlaintext":"LSD is the classic member of psychedelic lysergamides. Structural modifications to three main regions of the LSD scaffold have resulted in the emergence of new lysergamides entering the novel psychoactive substances (NPS) market. To support toxicologists and forensic chemists tasked with the identification of these drugs, this poster describes the common naming conventions used for lysergamides and presents common lysergamide substitutions, fragments, and tips for mass spectrometry interpretation to help the forensic community decipher the structure of new lysergamides. In this guide for lysergamide identification and naming, we review: Common lysergamide substitutions Common lysergamide MS fragments Proposed mechanism for some fragments Mass spectrum of 1P-LSD and tips for interpretation Review the list of primary resources used to collate this guide here. To cite this poster: Watson-Gooden, C., Pierzynski, H., Iula, D.M., and Hering, K.W. Laboratory Guide for Lysergamide Identification and Naming. September 2023.", "text1":["LSD is the classic member of psychedelic lysergamides. Structural modifications to three main regions of the LSD scaffold have resulted in the emergence of new lysergamides entering the novel psychoactive substances (NPS) market. To support toxicologists and forensic chemists tasked with the identification of these drugs, this poster describes the common naming conventions used for lysergamides and presents common lysergamide substitutions, fragments, and tips for mass spectrometry interpretation to help the forensic community decipher the structure of new lysergamides. In this guide for lysergamide identification and naming, we review: Common lysergamide substitutions Common lysergamide MS fragments Proposed mechanism for some fragments Mass spectrum of 1P-LSD and tips for interpretation Review the list of primary resources used to collate this guide here. To cite this poster: Watson-Gooden, C., Pierzynski, H., Iula, D.M., and Hering, K.W. Laboratory Guide for Lysergamide Identification and Naming. September 2023."], "contentType":"Document", "description":"This poster describes the common naming conventions used for lysergamides and presents common lysergamide substitutions, fragments, and tips for mass spectrometry interpretation to help the forensic community decipher the structure of new lysergamides.", "featured":true, "featuredImageFilename":"lysergamide-naming-poster-highlight.png", "fileUrl":"800246", "itemType":"Lab Wall Posters", "linkFileName":"800246.pdf", "linkFileName2":"800246.pdf", "order":"36000.0000000000", "publishDate":"2023-10-10T04:00:00Z", "requestType":"Both", "reviewDate":"2024-01-08T05:00:00Z", "tagline":"​Laboratory Guide for Lysergamide Identification and Naming
", "title":"

​Laboratory Guide for Lysergamide Identification and Naming

", "text10":["

​Laboratory Guide for Lysergamide Identification and Naming

"], "urlName":"Laboratory Guide for Lysergamide Identification and Naming", "text100":["Laboratory Guide for Lysergamide Identification and Naming"], "video":"0", "categories":["Forensic Chemistry & Toxicology"], "categoriesNormalized":["forensic_chemistry_and_toxicology"], "_version_":1807987999871336448}, { "id":"363", "axId":"800245", "a4Version":["0"], "blurb":"LNPs are primed to revolutionize modern medicine. This technology has immense possibilities to evolve beyond infectious disease to reach targets once considered undruggable and treat a near infinite number of conditions. In this issue of Cayman Currents, we showcase the ongoing discoveries and innovation advancing LNPs to the forefront of modern medicine and highlight tools available from Cayman to support LNP research. 

Articles: 
", "blurbPlaintext":"LNPs are primed to revolutionize modern medicine. This technology has immense possibilities to evolve beyond infectious disease to reach targets once considered undruggable and treat a near infinite number of conditions. In this issue of Cayman Currents, we showcase the ongoing discoveries and innovation advancing LNPs to the forefront of modern medicine and highlight tools available from Cayman to support LNP research. Articles: LNPs Beyond mRNA Vaccines – Where Do We Go from Here? Derisking LNP Development Through Early Investments in R&D", "text1":["LNPs are primed to revolutionize modern medicine. This technology has immense possibilities to evolve beyond infectious disease to reach targets once considered undruggable and treat a near infinite number of conditions. In this issue of Cayman Currents, we showcase the ongoing discoveries and innovation advancing LNPs to the forefront of modern medicine and highlight tools available from Cayman to support LNP research. Articles: LNPs Beyond mRNA Vaccines – Where Do We Go from Here? Derisking LNP Development Through Early Investments in R&D"], "contentType":"Document", "description":"In this issue of Cayman Currents, we showcase the ongoing discoveries and innovation advancing LNPs to the forefront of modern medicine and highlight tools available from Cayman to support LNP research. ", "featured":true, "featuredImageFilename":"LNP-currents-issue36-feature.png", "fileUrl":"800245", "itemType":"Cayman Currents", "linkFileName":"800245.pdf", "linkFileName2":"800245.pdf", "order":"36300.0000000000", "publishDate":"2023-11-02T04:00:00Z", "requestType":"Both", "reviewDate":"2024-01-31T05:00:00Z", "tagline":"​Cayman Currents Issue 36: Lipid Nanoparticles
", "title":"​Cayman Currents Issue 36: Lipid Nanoparticles
", "text10":["​Cayman Currents Issue 36: Lipid Nanoparticles
"], "urlName":"lnp current", "text100":["lnp current"], "video":"0", "categories":["Lipid-Based Drug Delivery", "Cancer", "Infectious Disease", "Immunology & Inflammation"], "categoriesNormalized":["lipid-based_drug_delivery", "cancer", "infectious_disease", "immunology_and_inflammation"], "_version_":1807987999875530752}, { "id":"370", "a4Version":["0"], "blurb":"

Key Features

To cite this application note: Taylor, D.J.R., Ji, J., Rzeczycki, P., et al. Encapsulation and transfection of RNA using LipidLaunch™ SM-102 Lipid Nanoparticles (Loadable). Application Note, Cayman Chemical (2024).
", "blurbPlaintext":"Key Features Cayman’s LipidLaunch™ SM-102 LNP Kit (Loadable) is comprised of lyophilized SM-102-based lipid nanoparticles (LNPs) prepared without cargo. Allows researchers to encapsulate RNA cargo of choice for LNP-mediated transfection without microfluidic mixing devices. Enable RNA delivery to difficult-to-transfect cell lines and primary cultures. LipidLaunch™ SM-102 LNPs (Loadable) facilitate effective RNA transfection with minimal cytotoxicity compared to traditional transfection reagents. To cite this application note: Taylor, D.J.R., Ji, J., Rzeczycki, P., et al. Encapsulation and transfection of RNA using LipidLaunch™ SM-102 Lipid Nanoparticles (Loadable). Application Note, Cayman Chemical (2024).", "text1":["Key Features Cayman’s LipidLaunch™ SM-102 LNP Kit (Loadable) is comprised of lyophilized SM-102-based lipid nanoparticles (LNPs) prepared without cargo. Allows researchers to encapsulate RNA cargo of choice for LNP-mediated transfection without microfluidic mixing devices. Enable RNA delivery to difficult-to-transfect cell lines and primary cultures. LipidLaunch™ SM-102 LNPs (Loadable) facilitate effective RNA transfection with minimal cytotoxicity compared to traditional transfection reagents. To cite this application note: Taylor, D.J.R., Ji, J., Rzeczycki, P., et al. Encapsulation and transfection of RNA using LipidLaunch™ SM-102 Lipid Nanoparticles (Loadable). Application Note, Cayman Chemical (2024)."], "contentType":"Document", "description":"Cayman’s LipidLaunch™ SM-102 LNP Kit (Loadable) is comprised of lyophilized SM-102-based lipid nanoparticles (LNPs) prepared without cargo.", "featured":true, "featuredImageFilename":"lipidLaunch-LNP-app-note-highlight.png", "fileUrl":"LipidLaunch LNP app note", "itemType":"Application notes", "linkFileName":"LipidLaunch LNP app note.pdf", "linkFileName2":"LipidLaunch LNP app note.pdf", "order":"37000.0000000000", "publishDate":"2024-02-29T05:00:00Z", "requestType":"Downloadable", "reviewDate":"2024-05-29T04:00:00Z", "tagline":"Encapsulation and Transfection of RNA Using LipidLaunch™ SM-102 Lipid Nanoparticles (Loadable)
", "title":"Encapsulation and Transfection of RNA Using LipidLaunch™ SM-102 Lipid Nanoparticles (Loadable)
", "text10":["Encapsulation and Transfection of RNA Using LipidLaunch™ SM-102 Lipid Nanoparticles (Loadable)
"], "urlName":"Encapsulation of RNA via LipidLaunch loadable lnps", "text100":["Encapsulation of RNA via LipidLaunch loadable lnps"], "video":"0", "categories":["Cell Biology", "Cancer", "Immunology & Inflammation", "Infectious Disease", "Lipid-Based Drug Delivery"], "categoriesNormalized":["cell_biology", "cancer", "immunology_and_inflammation", "infectious_disease", "lipid-based_drug_delivery"], "_version_":1807987999899648000}] }}